Accounts in Drug Discovery: Case Studies in Medicinal Chemistry
The case studies include medicinal chemistry stories on recently approved and marketed drugs, but also chronicle "near-misses", i.e., exemplary compounds that may have proceeded well into the clinic but for various reasons did not result in a successful registration. As the vast majority of projects fail prior to registration, much can be learned from such narratives. By sharing a wide range of drug discovery experiences and information across the community of medicinal chemists in both industry and academia, we believe that these ***s will provide insights into the art of medicinal chemistry as it is currently practiced and will help to serve the needs of active medicinal chemists.
Burgers Medicinal Chemistry and Drug Discovery. Volume 1: Drug Discovery (6th edition)
Completely updated and revised to reflect the many monumental changes that have occurred in the field, this latest edition brings together contributions by experts in a wide range of related fields to explore recent advances in the understanding of the structural biology of drug action, as well as cutting-edge technologies for drug discovery now in use around the world.
This is Volume 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery.
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Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery and Drug Development (Volume 2) by Donald J. Abraham
This new edition of Dr. Alfred Burger's internationally celebrated classic helps researchers acquaint themselves with both traditional and state-of-the-art principles and practices governing new medicinal drug research and development. Completely updated and revised to reflect the many monumental changes that have occurred in the field, this latest edition brings together contributions by experts in a wide range of related fields to explore recent advances in the understanding of the structural biology of drug action, as well as cutting-edge technologies for drug discovery now in use around the world.
This Sixth Edition of Burger's Medicinal Chemistry and Drug Discovery has been expanded to six volumes:
Volume 1: Drug Discovery
Volume 2: Drug Discovery and Drug Development
Volume 3: Cardiovascular Agents and Endocrines
Volume 4: Autocoids, Diagnostics, and Drugs from New Biology
Volume 5: Chemotherapeutic Agents
Volume 6: Nervous System Agents
This is Volume 2: Drug Discovery and Drug Development, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Combinational Chemistry and Multiple Parallel Synthesis, High Throughput Pharmacology, and Retrometabolism-Based Drug Design and Targeting.
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Burger's Medicinal Chemistry and Drug Discovery, Chemotherapeutic Agents (Volume 5) by Donald J. Abraham
This new edition of Dr. Alfred Burger's internationally celebrated classic helps researchers acquaint themselves with both traditional and state-of-the-art principles and practices governing new medicinal drug research and development. Completely updated and revised to reflect the many monumental changes that have occurred in the field, this latest edition brings together contributions by experts in a wide range of related fields to explore recent advances in the understanding of the structural biology of drug action, as well as cutting-edge technologies for drug discovery now in use around the world.
This Sixth Edition of Burger's Medicinal Chemistry and Drug Discovery has been expanded to six volumes:
Volume 1: Drug Discovery
Volume 2: Drug Discovery and Drug Development
Volume 3: Cardiovascular Agents and Endocrines
Volume 4: Autocoids, Diagnostics, and Drugs from New Biology
Volume 5: Chemotherapeutic Agents
Volume 6: Nervous System Agents
This is Volume 5: Chemotherapeutic Agents, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Molecular Biology of Cancer, Synthetic Anti-angiogenic Agents and Selective Toxicities.
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Alfred Burger, Donald J. Abraham - Burger
This new edition of Dr. Alfred Burger's internationally celebrated classic helps researchers acquaint themselves with both traditional and state-of-the-art principles and practices governing new medicinal drug research and development. Completely updated and revised to reflect the many monumental changes that have occurred in the field, this latest edition brings together contributions by experts in a wide range of related fields to explore recent advances in the understanding of the structural biology of drug action, as well as cutting-edge technologies for drug discovery now in use around the world.
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Drug Design: Structure- and Ligand-Based Approaches
Topics covered include X-ray crystallography, NMR, fragment-based drug design, free energy methods, docking and scoring, linear-scaling quantum calculations, QSAR, pharmacophore methods, computational ADME-Tox, and drug discovery case studies.
A variety of authors from academic and commercial institutions all over the world have contributed to this book, which is illustrated with more than 200 images. This is the only book to cover the subject of structure and ligand-based drug design, and it provides the most up-to-date information on a wide range of topics for the practicing computational chemist, medicinal chemist, or structural biologist.
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Bioorganic and Medicinal Chemistry 2010 2011
The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A Special feature Will be That Colour illustrations Will be reproduced at no charge to the Author, Provided That the Editor agrees That Colour is Essential to the information content of the Illustration in question
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Modern Phytomedicine: Turning Medicinal Plants into Drugs
Manuel Hidalgo, "Principles of Anticancer Drug Development (Cancer Drug Discovery and Development)
A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.
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Dynamic Combinatorial Chemistry: In Drug Discovery, Bioorganic Chemistry, and Materials Science
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*******Rosea&Winter********
Microwave-Assisted Synthesis of Heterocycles
This book is Volume I of a new series by Springer entitled Topics in Heterocyclic Chemistry. At present, there are six such monographs in this series, the overall scope of which is to cover "current trends in heterocyclic chemistry". Given the importance of heterocylic natural products and heterocyclic scaffolds in the realm of medicinal chemistry and drug discovery, an up-todate series on this subject is well warranted, and a survey of the recent impact of microwave-assisted synthesis on this venerable field is both timely and needed........... Overall, this is a well thoughtout, up-to-date, and informative text written by the many of the leaders in this emerging field. While the editors and authors have done an admirable job of presenting a snapshot of the current state of microwave-assisted heterocyclic chemistry, they have also exposed the fact that much remains to be done in this area, a feat that may be accomplished when this powerful technique has achieved greater acceptance. Finally, although the publication of this volume coincides with the introduction of several excellent monographs on microwave chemistry to the market, the value of the present text is not diminished by these more comprehensive surveys of the topic, in which the coverage of heterocyles is typically limited to a single chapter.
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Innovation in the Pharmaceutical Industry - The Process of Drug Discovery and Development by Takuji Hara
Innovation in the Pharmaceutical Industry traces the discovery and development of drugs in Japan and the UK both historically and sociologically. It includes sixteen case studies of major pharmaceutical developments in the twentieth century, encompassing, among others, beta-blockers, beta-stimulants, inhaled steroids and histamine H2-antagonists. The book illustrates that the four stages of drug development - namely compound, application, organizational authorization and market - are interactively shaped by heterogeneous actors and institutions. The book also identifies three different types of pharmaceutical development - paradigmatic innovation, application innovation and modification-based innovation, all with distinguishable features in the drug development process. Finally, several historical, structural and cultural factors influencing the shaping of medicines are revealed by the comparison between British and Japanese drug innovation.
Addressing a number of practical implications for the promotion of the pharmaceutical industry, this book will be of enormous interest to students, researchers and academics specializing in science and technology, and the management of technology and innovation. Practitioners, managers, and policy planners within the pharmaceutical industry will also deem this book invaluable.
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Pharmaceutical Data Mining: Approaches and Applications for Drug Discovery
In the era of post-genomic drug development, extracting and applying knowledge from chemical, biological, and clinical data is one of the greatest challenges facing the pharmaceutical industry. Pharmaceutical Data Mining brings together contributions from leading academic and industrial scientists, who address both the implementation of new data mining technologies and application issues in the industry. This accessible, comprehensive collection discusses important theoretical and practical aspects of pharmaceutical data mining, focusing on diverse approaches for drug discovery
Modern Phytomedicine: Turning Medicinal Plants into Drugs by Iqbal Ahmad, Farrukh Aqil, Mohammad Owais Wiley-VCH 2007-02-01
This timely and original handbook paves the way to success in plant-based drug development, systematically addressing the issues facing a pharmaceutical scientist who wants to turn a plant compound into a safe and effective drug. Plant pharmacologists from around the world demonstrate the potentials and pitfalls involved, with many of the studies and experiments reported here published for the first time. The result is a valuable source of information unavailable elsewhere.
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Reliable Knowledge Discovery
Reliable Knowledge Discovery focuses on theory, methods, and techniques for RKDD, a new sub-field of KDD. It studies the theory and methods to assure the reliability and trustworthiness of discovered knowledge and to maintain the stability and consistency of knowledge discovery processes. RKDD has a broad spectrum of applications, especially in critical domains like medicine, finance, and military. Reliable Knowledge Discovery also presents methods and techniques for designing robust knowledge-discovery processes. Approaches to assessing the reliability of the discovered knowledge are introduced. Particular attention is paid to methods for reliable feature selection, reliable graph discovery, reliable classification, and stream mining. Estimating the data trustworthiness is covered in this volume as well. Case studies are provided in many chapters. Reliable Knowledge Discovery is designed for researchers and advanced-level students focused on computer science and electrical engineering as a secondary text or reference. Professionals working in this related field and KDD application developers will also find this book useful.
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Annual Reports in Medicinal Chemistry, Volume 39
The Organic Chemistry of Drug Design and Drug Action
...
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Fragment-Based Drug Discovery and X-Ray Crystallography
Bayesian Artificial Intelligence, 2nd Edition
Bayesian Artificial Intelligence, 2nd Edition
Publisher: C.R.C Press | 2011 | 491 Pages | ISBN: 1439815917 | PDF | 3 MB (HF+FSN)
Updated and expanded, Bayesian Artificial Intelligence, Second Edition provides a practical and accessible introduction to the main concepts, foundation, and applications of Bayesian networks. It focuses on both the causal discovery of networks and Bayesian inference procedures. Adopting a causal interpretation of Bayesian networks, the authors discuss the use of Bayesian networks for causal modeling. They also draw on their own applied research to illustrate various applications of the technology.
New to the Second Edition
New chapter on Bayesian network classifiers
New section on object-oriented Bayesian networks
New section that addresses foundational problems with causal discovery and Markov blanket discovery
New section that covers methods of evaluating causal discovery programs
Discussions of many common modeling errors
New applications and case studies
More coverage on the uses of causal interventions to understand and reason with causal Bayesian networks
Illustrated with real case studies, the second edition of this bestseller continues to cover the groundwork of Bayesian networks. It presents the elements of Bayesian network technology, automated causal discovery, and learning probabilities from data and shows how to employ these technologies to develop probabilistic expert systems.
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Antisense Drug Technology: Principles, Strategies, and Applications
Presents previously unpublished data on the use of antisense technology to dissect pharmacological processes and confirm the roles of various genes!
Showcasing the benefits of antisense drug use, including reduced toxicity and earlier disease detection, Antisense Drug Technology discusses
novel formulations of antisense drugs
practical methods to design effective isotype selective inhibitors
molecular mechanisms of antisense drugs
mRNA as a current biological template
modern postreceptor binding mechanisms
and more!
With contributions by over 60 seasoned experts in the field and containing more than 3000 helpful references, tables, drawings, and photographs, Antisense Drug Technology is an illuminating source for organic, medicinal, and pharmaceutical chemists; biochemists; geneticists; hematologists; oncologists; molecular and cell biologists; virologists; immunologists; and medical school and graduate students in these disciplines.
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Related Posts Accounts in Drug Discovery Case Studies in Medicinal Chemistry:
- Burger s Medicinal Chemistry and Drug Discovery Drug Discovery and Drug Development Volume 2 by Donald J. Abraham
- Burgers Medicinal Chemistry and Drug Discovery. Volume 1 Drug Discovery 6th edition
- Burger s Medicinal Chemistry and Drug Discovery Chemotherapeutic Agents Volume 5 by Donald J. Abraham
- Dynamic Combinatorial Chemistry In Drug Discovery Bioorganic Chemistry and Materials Science
- Manuel Hidalgo Principles of Anticancer Drug Development Cancer Drug Discovery and Development
- The Organic Chemistry of Drug Design and Drug Action
- Fragment Based Drug Discovery and X Ray Crystallography
- Enzyme Inhibition in Drug Discovery and Development The Good and the Bad
- The Tumor Microenvironment Cancer Drug Discovery and Development
- Pharmaceutical Data Mining Approaches and Applications for Drug Discovery
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